About HyloFlex™

Joint health is a real concern for any animal. We want to keep our pets and livestock sound and make certain they are comfortable and able to perform at the highest level. Healthy joint fluid (Synovial fluid) protects joints by providing cushion and lubrication within the joint. Synovial fluid is critical to reducing the stress and friction created during movement. By allowing the cartilage to slide against one another safely, friction is minimized which promotes mobility and flexibility.  

​Reduction, breakdown and changes in the quality of the Synovial fluid is particularly common and occurs from weight gain, stress, exercise, age and injuries. This breakdown eventually causes inflammation, arthritis, and pain. Other common signs of Synovial fluid breakdown are blown hocks, popping or clicking in the pasterns, flexibility or movement issues and lameness. 

 

HyloFlex™ is an all-natural, liquid Hyaluronic Acid (HA) feed supplement consisting of high-molecular weight HA in its purest form, plus Vitamin C. HyloFlex™ works to replenish the fluid in the joints, with results usually in 7-10 days.

HyloFlex™ can be used as a preventative measure in younger animals, or at a higher dosage in mature animals when pain and soundness issues occur or for those already suffering from injury, arthritis or inflammation symptoms.

 

HyloFlex™ is also designed to go far beyond other similar supplements in several very important ways: 

High molecular weight in its purest form and bio-available.

HA sources vary widely among supplements and most use HA derived from rooster combs (9% purity) or hydrolyzed chicken cartilage (~10%purity). These are very low molecular weight, have very different biological and physical properties, and do not
have the lubricating properties that high molecular weight HA has. Published research studies 
(referenced at the bottom) have confirmed that high molecular weight, protein-free HA has the greatest biological response rate, because it replicates the native HA that is naturally produced in the body. It is absorbed faster and stays in the tissues longer. 

Oral application, no injections needed.

Before oral HA can be broken down and incorporated into the system it must be properly hydrated. This process may take up to 18 hours. For this reason; the liquid form (pre-hydrated) is a much better choice for oral HA supplementation than the dry pellets or powders which can also be left behind in the food bowl or feeder. Oral application also means there is no need for invasive, higher risk, and inconvenient injections 

 

Vitamin C.

Vitamin C is an additional ingredient in HyloFlex™. Vitamin C is an important antioxidant that plays a protective role in the body. It protects the body against damage from free radicals largely responsible for many degenerative diseases. It plays a critical role in the body’s immune system function as it stimulates production of interferon and antibodies that fight bacteria and viruses to protect against infections and illnesses.

 

Vitamin C is also needed to make collagen, the protein necessary for the formation and repair of blood capillaries and connective tissue such as cartilage, skin, bone, tendons and ligaments, thus assisting in the absorption of HyloFlex™

 

Animals under the stress of competition, exercise, transportation or just normal aging, will benefit from Vitamin C supplementation.

 

Concentrated dosage.

HyloFlex™ has 204mg of HA per mL, which means the dosage is just 2mL per 100lbs of body weight, and can be easily administered via food, water, or drenching. Doses should be doubled for the first 10 days and during times of stress, injury recovery, or for older animals.


HyloFlex is safe to use on all species with no risk of overdose or toxicity. 

Easy Administration, Fast-Acting & Long Lasting 
 
HyloFlex™ can be administered via feed, water, or drenching. It is absorbed in the upper GI tract and is distributed straight to the joints for fast results in a week to ten days, and remains in the tissue for as long as 72 hours. This is longer than injectable HA supplementation. 

 

Safe, Natural, Non-Testing & Non-Invasive Joint Support

HyloFlex™ is a safe and non-invasive option for protecting the joints of cattle, swine, sheep, goats, horses and domestic pets. It is non-testing and safe to use in all settings and species. A safe and effective alternative to injections and prohibited medications. 

*References

 

Bucci, LR, and AA Turpin. “Will the real hyaluronan please stand up?” J of Appl Nutr 54, no. 1 (2004): 10-33.

 

Schauss, AG, LG Balogh, AG Polyak, RG Kiraly, and i GG Janok. “Absorption, distribution and excretion of 99mtechnetium labeled hyaluronan after single oral doses in rats and beagle dogs.” FASEB j 18, no. 4 (2004): A150-151.

 

Cantor, JO, and PP Nadkarni. “Hyaluronan: the Jekyll and Hyde molecule.” Inflamm Allergy Drug Targets 5, no. 4 (Dec 2006): 257-260.

 

Gotoh, S, et al. “Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats.” Ann Rheum Dis 52, no. 11 (Nov 1993): 817-822.

 

Nakamura, K, et al. “High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in mice.” J Gastroenterol 39, no. 4 (2004): 346-354.
Novartis. Clinical Studies. 2005. http://www.adequancanine.us/vet/en/vet_clinicalStudies.shtml (accessed Feb 22, 2007).

 

Ishimaru, JI, N Ogi, S Mizuno, and AN Goss. “Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints.” Osteoarthritis Cartilage 9, no. 4 (May 2001): 365-370.

 

Moreland, LW. “Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action.” Arthritis Res Ther 5, no. 2 (2003): 54-67.

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